![]() ![]() An example of a molecule that is chemically a thiazide but not used as a diuretic is methylchloroisothiazolinone, often found as an antimicrobial in cosmetics. Thiazide diuretics inhibit this receptor, causing the body to release NaCl and water into the lumen, thereby increasing the amount of urine produced each day. The thiazide receptor is a sodium-chloride transporter that pulls NaCl from the lumen in the distal convoluted tubule. When used this way, "thiazide" refers to a drug which acts at the thiazide receptor. Confusion sometimes occurs because thiazide-like diuretics such as indapamide are referred to as thiazides despite not having the thiazide chemical structure. Thiazide organic molecules are bi-cyclic structures that contain adjacent sulfur and nitrogen atoms on one ring. ![]() In most countries, thiazides are the least expensive antihypertensive drugs available. The first approved drug of this class, chlorothiazide, was marketed under the trade name Diuril beginning in 1958. The thiazide drug class was discovered and developed at Merck and Co. Thiazide ( / ˈ θ aɪ ə z aɪ d/) refers to both a class of sulfur-containing organic molecules and a class of diuretics based on the chemical structure of benzothiadiazine. Benzothiadiazine, the parent structure of this class of molecules ![]()
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